Asymmetric syntheses of epohelmins A and B by In-mediated allylation.
نویسندگان
چکیده
A diastereoselective new approach for the synthesis of trans-4-hydroxy-5-allyl-2-pyrrolidinone 9 has been developed through In-mediated allylation of α-chiral aldimine 8 with allyl bromide. The stereochemistry at the C-2 stereogenic center of 9 was controlled by both the α-OTBS substitution and the sulfinamide moiety. The utility of this asymmetric allylation is demonstrated by the asymmetric syntheses of epohelmins A (4) and B (10).
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 14 45 شماره
صفحات -
تاریخ انتشار 2016